What Is a Free Testosterone Blood Test?

Free testosterone is the unbound, biologically active form — only 1–3% of total testosterone.

Why Test Free T?

  • Total T can be misleading
  • SHBG binds testosterone — high SHBG = low free T
  • Symptoms may reflect free T, not total T

Factors Affecting SHBG

  • High SHBG: aging, liver disease, hyperthyroidism, estrogen
  • Low SHBG: obesity, insulin resistance, hypothyroidism

When to Test Free T

  • Symptoms of low T but total T is borderline
  • Conditions affecting SHBG
  • Monitoring TRT effectiveness
Source: Endocrine Society, NLM MedlinePlus.

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