What Is Mean Platelet Volume (MPV)?

Q: What Is Mean Platelet Volume (MPV)?

MPV measures average platelet size. High MPV = younger, larger platelets (increased production). Low MPV = older, smaller platelets (decreased production).

MPV measures the average size of platelets. Larger platelets are younger and more clot-active.

Normal Range

7.5–11.5 fL

High MPV

Increased platelet destruction (ITP)
Recent surgery
Cardiovascular risk
Hyperthyroidism

Low MPV

Bone marrow suppression
Chemotherapy
Aplastic anemia

Clinical Use

Interpret with platelet count
High MPV + low count = marrow compensating
Low MPV + low count = production failure

Source: NLM MedlinePlus, American Association for Clinical Chemistry.

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