What Is Globulin in a Blood Test?

Q: What Is Globulin in a Blood Test?

Globulins are blood proteins including antibodies. High globulin suggests infection, inflammation, or plasma cell disorders. Low globulin suggests liver disease or malnutrition.

Globulins are a group of blood proteins that include antibodies (immunoglobulins), transport proteins, and clotting factors.

Normal Range

2.3–3.5 g/dL
Calculated as: Total protein − Albumin

High Globulin

Chronic infection
Autoimmune disease
Multiple myeloma
Liver disease
Inflammation

Low Globulin

Liver disease
Malnutrition
Kidney disease (protein loss)
Immune deficiency

Source: NLM MedlinePlus, American Association for Clinical Chemistry.

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