What Does High MCV Mean?

High MCV means your red blood cells are larger than normal (macrocytosis).

Common Causes

  • Vitamin B12 deficiency — impaired DNA synthesis
  • Folate deficiency
  • Alcohol use disorder
  • Liver disease
  • Hypothyroidism
  • Certain medications — methotrexate, phenytoin

Next Steps

  • Check vitamin B12 and folate levels
  • Check TSH
  • Evaluate alcohol use
  • Check methylmalonic acid if B12 borderline
Source: NLM MedlinePlus, American Association for Clinical Chemistry.

Ratings summarize government-reported measures — they don't capture your personal needs. Visit the facility, ask about staffing and services, and use CMS checklists. This profile is informational only and is not a recommendation.

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