What Does High ALT Mean?

Q: What Does High ALT Mean?

High ALT (above 56 U/L) indicates liver cell damage. Most common cause: fatty liver disease. Other: hepatitis, medications, alcohol. Mild elevations often resolve on recheck.

High ALT indicates liver cells are damaged or inflamed, leaking the enzyme into blood.

Common Causes

Fatty liver disease (NAFLD) — most common cause
Viral hepatitis B or C
Alcohol use
Medications — statins, acetaminophen, antibiotics
Autoimmune hepatitis
Intense exercise (temporary)

Severity

Mild (1-3x normal): often NAFLD — repeat in 6-8 weeks
Moderate (3-10x): investigate — hepatitis serologies
Marked (10x+): urgent evaluation

Next Steps

Repeat testing
Check AST (AST:ALT ratio helps identify cause)
Viral hepatitis panel
Liver ultrasound
Review all medications and supplements

Source: NLM MedlinePlus, American Association for Clinical Chemistry.

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