Zonisamide: Side Effects, Uses & Monitoring
Facts extracted from current FDA product labeling for Zonisamide. Educational only — not medical advice.
Reported adverse reactions
| Reaction | Highest frequency reported* |
|---|---|
| Somnolence | 17% |
| Anorexia | 13% |
| Dizziness | 13% |
| Headache | 10% |
| Nausea | 9% |
| Agitation/irritability | 9% |
| Fatigue | 8% |
| Tiredness | 7% |
| Abdominal pain | 6% |
| Ataxia | 6% |
| Confusion | 6% |
| Difficulty concentrating | 6% |
| Difficulty with memory | 6% |
| Depression | 6% |
| Insomnia | 6% |
| Diplopia | 6% |
| Diarrhea | 5% |
| Speech abnormalities | 5% |
| Flu syndrome | 4% |
| Nystagmus | 4% |
*Highest percentage across placebo-controlled trial tables summarized in current labeling.
Labeled uses
Zonisamide capsules USP are indicated as adjunctive therapy in the treatment of partial seizures in adults with epilepsy.
Source: FDA labeling via NIH DailyMed (set b20a51ef…). Not affiliated with FDA or NIH.
Medical disclaimer: Always consult a qualified healthcare professional about any medication.