Trazodone: Side Effects, Uses & Monitoring
Facts extracted from current FDA product labeling for Trazodone. Educational only — not medical advice.
Reported adverse reactions
| Reaction | Highest frequency reported* |
|---|---|
| Drowsiness | 40.8% |
| Dry mouth | 33.8% |
| Dizziness/lightheadedness | 28% |
| Headache | 19.8% |
| Nervousness | 14.8% |
| Blurred vision | 14.7% |
| Nausea/vomiting | 12.7% |
| Insomnia | 12% |
| Fatigue | 11.3% |
| Constipation | 7.6% |
| Confusion | 7.6% |
| Skin condition/edema | 7% |
| Hypotension | 7% |
| Tachycardia/palpitations | 7% |
| Anger/hostility | 6.3% |
| Excitement | 5.7% |
| Abdominal/gastric disorder | 5.7% |
| Nasal/sinus congestion | 5.7% |
| Nightmares/vivid dreams | 5.7% |
| Weight loss | 5.7% |
*Highest percentage across placebo-controlled trial tables summarized in current labeling.
Labeled uses
Trazodone hydrochloride tablets are indicated for the treatment of depression. The efficacy of trazodone has been demonstrated in both inpatient and outpatient settings and for depressed patients with and without prominent anxiety. The depressive illness of patients studied corresponds to the Major Depressive Episode criteria of the American Psychiatric Association's Diagnostic and Statistical Manual, III.a Major Depressive Episode implies a prominent and relatively persistent (nearly every day for at least two weeks) depressed or dysphoric mood that usually interferes with daily functioning, and includes at least four of the following eight symptoms: change in appetite, change in sleep, psychomotor agitation or retardation, loss of interest in usual activities or decrease in sexual drive, increased fatigability, feelings of guilt or worthlessness, slowed thinking or impaired concentration, and suicidal ideation or attempts.
Medical disclaimer: Always consult a qualified healthcare professional about any medication.