Midodrine: Side Effects, Uses & Monitoring
Facts extracted from current FDA product labeling for Midodrine. Educational only — not medical advice.
Reported adverse reactions
| Reaction | Highest frequency reported* |
|---|---|
| Total # of reports | 77% |
| Paresthesia | 18.3% |
| Piloerection | 13.4% |
| Dysuria | 13.4% |
| Pruritus | 12.2% |
| Supine hypertension | 7.3% |
| Chills | 4.9% |
| Pain | 4.9% |
| Rash | 2.4% |
*Highest percentage across placebo-controlled trial tables summarized in current labeling.
Labeled uses
Midodrine hydrochloride tablets are indicated for the treatment of symptomatic orthostatic hypotension (OH). Because midodrine hydrochloride tablets can cause marked elevation of supine blood pressure (BP > 200 mmHg systolic), it should be used in patients whose lives are considerably impaired despite standard clinical care, including non-pharmacologic treatment (such as support stockings), fluid expansion, and lifestyle alterations. The indication is based on midodrine hydrochloride tablets's effect on increases in 1-minute standing systolic blood pressure, a surrogate marker considered likely to correspond to a clinical benefit. At present, however, clinical benefits of midodrine hydrochloride tablets, principally improved ability to perform life activities, have not been established. Further clinical trials are underway to verify and describe the clinical benefits of midodrine hydrochloride tablets. After initiation of treatment, midodrine hydrochloride tablets should be continued only for patients who report significant symptomatic improvement.
Medical disclaimer: Always consult a qualified healthcare professional about any medication.