Leuprolide: Side Effects, Uses & Monitoring
Facts extracted from current FDA product labeling for Leuprolide. Educational only — not medical advice.
Reported adverse reactions
| Reaction | Highest frequency reported* |
|---|---|
| Gynecomastia/breast tenderness or pain | 63% |
| Hot flashes | 55% |
| Peripheral edema | 30% |
| Ecg changes/ischemia | 22% |
| Nausea/vomiting | 17% |
| General pain | 13% |
| Impotence | 12% |
| Phlebitis/thrombosis | 10% |
| Asthenia | 10% |
| Constipation | 9% |
| Myalgia | 9% |
| High blood pressure | 8% |
| Murmur | 8% |
| Dyspnea | 8% |
| Dermatitis | 8% |
| Frequency/urgency | 8% |
| Dizziness/lightheadedness | 7% |
| Headache | 7% |
| Insomnia/sleep disorders | 7% |
| Urinary tract infection | 7% |
*Highest percentage across placebo-controlled trial tables summarized in current labeling.
Labeled uses
Leuprolide acetate injection is indicated in the palliative treatment of advanced prostatic cancer.
Source: FDA labeling via NIH DailyMed (set a3b01473…). Not affiliated with FDA or NIH.
Medical disclaimer: Always consult a qualified healthcare professional about any medication.