Estradiol: Side Effects, Uses & Monitoring
Facts extracted from current FDA product labeling for Estradiol. Educational only — not medical advice.
Reported adverse reactions
| Reaction | Highest frequency reported* |
|---|---|
| Urogenital | 63% |
| Body as a whole | 48% |
| Respiratory | 38% |
| Breast pain | 31% |
| Nervous | 28% |
| Digestive | 24% |
| Dysmenorrhea | 21% |
| Headache | 20% |
| Skin and appendages | 17% |
| Musculoskeletal | 17% |
| Rhinitis | 13% |
| Vaginitis | 13% |
| Metabolic and nutritional disorders | 13% |
| Asthenia | 12% |
| Respiratory disorder | 12% |
| Menstrual disorder | 12% |
| Vaginal hemorrhage | 12% |
| Back pain | 11% |
| Nausea | 11% |
| Pharyngitis | 10% |
*Highest percentage across placebo-controlled trial tables summarized in current labeling.
Labeled uses
CombiPatch is indicated in a woman with a uterus for: Treatment of moderate to severe vasomotor symptoms due to menopause. Treatment of moderate to severe symptoms of vulvar and vaginal atrophy due to menopause. When prescribing solely for the treatment of symptoms of vulvar and vaginal atrophy, topical vaginal products should be considered. Treatment of hypoestrogenism due to hypogonadism, castration, or primary ovarian failure.
Source: FDA labeling via NIH DailyMed (set 83198ef1…). Not affiliated with FDA or NIH.
Medical disclaimer: Always consult a qualified healthcare professional about any medication.