Duloxetine: Side Effects, Uses & Monitoring
Facts extracted from current FDA product labeling for Duloxetine. Educational only — not medical advice.
Reported adverse reactions
| Reaction | Highest frequency reported* |
|---|---|
| Nauseac | 23% |
| Nausea | 23% |
| Headache | 14% |
| Decreased weightd | 14% |
| Dry mouth | 13% |
| Dry mouthb | 11% |
| Fatigued | 11% |
| Somnolenceb,f | 11% |
| Somnolence e | 10% |
| Constipationb | 10% |
| Agitationi | 10% |
| Fatigueb,c | 9% |
| Insomnia d | 9% |
| Constipationc | 9% |
| Dizziness c | 9% |
| Diarrhea | 9% |
| Dizziness | 9% |
| Decreased appetiteb | 8% |
| Decreased appetitec | 7% |
| Fatiguec | 7% |
*Highest percentage across placebo-controlled trial tables summarized in current labeling.
Labeled uses
1 INDICATIONS AND USAGE Duloxetine delayed-release capsules are indicated for the treatment of: Major Depressive Disorder [SEE CLINICAL STUDIES (14.1)] Generalized Anxiety Disorder [SEE CLINICAL STUDIES (14.2)] Diabetic Peripheral Neuropathy [SEE CLINICAL STUDIES (14.3)] Fibromyalgia [see CLINICAL STUDIES (14.4)] Chronic Musculoskeletal Pain [SEE CLINICAL STUDIES (14.5)]
Source: FDA labeling via NIH DailyMed (set afd59273…). Not affiliated with FDA or NIH.
Medical disclaimer: Always consult a qualified healthcare professional about any medication.