Digoxin: Side Effects, Uses & Monitoring

Facts extracted from current FDA product labeling for Digoxin. Educational only — not medical advice.

Reported adverse reactions

ReactionHighest frequency reported*
Mental disturbances4%
Death2%
Heart arrest1%
Abdominal pain1%

*Highest percentage across placebo-controlled trial tables summarized in current labeling.

Labeled uses

Heart Failure: Digoxin is indicated for the treatment of mild to moderate heart failure. Digoxin increases left ventricular ejection fraction and improves heart failure symptoms as evidenced by exercise capacity and heart failure symptoms as evidenced by exercise capacity and heart failure-related hospitalizations and emergency care, while having no effect on mortality. Where possible, digoxin should be used with a diuretic and an angiotensin-converting enzyme inhibitor, but an optimal order for starting these three drugs cannot be specified. Atrial Fibrillation: Digoxin is indicated for the control of ventricular response rate in patients with chronic atrial fibrillation.

Source: FDA labeling via NIH DailyMed (set fb21e756…). Not affiliated with FDA or NIH.

Medical disclaimer: Always consult a qualified healthcare professional about any medication.