Bupropion: Side Effects, Uses & Monitoring
Facts extracted from current FDA product labeling for Bupropion. Educational only — not medical advice.
Reported adverse reactions
| Reaction | Highest frequency reported* |
|---|---|
| Headache | 34% |
| Dry mouth | 26% |
| Insomnia | 20% |
| Nausea | 13% |
| Nasopharyngitis | 13% |
| Constipation | 9% |
| Infection | 9% |
| Anxiety | 7% |
| Flatulence | 6% |
| Dizziness | 6% |
| Sinusitis | 5% |
| Cough | 4% |
| Decreased appetite | 4% |
| Tremor | 3% |
| Abnormal dreams | 3% |
| Myalgia | 3% |
| Pain in extremity | 3% |
| Feeling jittery | 3% |
| Rash | 3% |
| Tinnitus | 3% |
*Highest percentage across placebo-controlled trial tables summarized in current labeling.
Labeled uses
Major Depressive Disorder: Bupropion hydrochloride extended-release tablets (XL) are indicated for the treatment of major depressive disorder. The efficacy of bupropion in the treatment of a major depressive episode was established in two 4-week controlled trials of inpatients and in one 6-week controlled trial of outpatients whose diagnoses corresponded most closely to the Major Depression category of the APA Diagnostic and Statistical Manual (DSM) (see CLINICAL TRIALS ). A major depressive episode (DSM-IV) implies the presence of 1) depressed mood or 2) loss of interest or pleasure; in addition, at least 5 of the following symptoms have been present during the same 2-week period and represent a change from previous functioning: depressed mood, markedly diminished interest or pleasure in usual activities, significant change in weight and/or appetite, insomnia or hypersomnia, psychomotor agitation or retardation, increased fatigue, feelings of guilt or worthlessness, slowed thinking or impaired concentration, a suicide attempt, or suicidal ideation. The efficacy of bupropion in maintaining an antidepressant response for up to 44 weeks following 8 weeks of acute treatment was demons…
Medical disclaimer: Always consult a qualified healthcare professional about any medication.